The methodology enabled the synthesis of a number of compounds with different functional groups that were obtained in good yields. Organoselenium compounds modulate extracellular redox by induction of extracellular. Selenium belongs with oxygen and sulfur to the group 16 elements or chalcogens, and similarities in chemistry are to be expected. This book discusses organoselenium chemistry and biology in the context of its therapeutic potential, taking.
The chemistry chapters are organized according to the different reactivities of various. Synthesis and antioxidant properties of organosulfur and. Organoselenium compounds in biology and medicine rsc. Synthesis, biological and therapeutic treatments on.
Organoselenium compound an overview sciencedirect topics. Organoselenium compounds as the oxidants and oxidation. Organoselenium compound article about organoselenium. Diorgano diseleniumi compounds compounds from this class have attracted considerable interest in the last decade. Organoselenium compounds as phytochemicals from the natural kingdom hanane achibat, nohad a alomari, federica messina, luca sancineto, mostafa khouili, and claudio santi natural product communications 2015 10. Chemoprevention of carcinogenesis by organoselenium. Pdf chemistry of biologically important synthetic organoselenium. Organoselenium compounds as antitumor agents this pdf is available for free download from a site hosted by medknow publications. Organoselenium compounds in biology and medicine pdf libribook. Achibat h, alomari na, messina f, sancineto l, khouili m, santi c.
Organoselenium chemistry is the corresponding science exploring their properties and reactivity. Keto acid metabolites of organoselenium compounds inhibit. Phosphorus, sulfur, and silicon and the related elements. Download hires image download to mspowerpoint cite this.
Organoselenium in nature is the title of the third chapter, which equips readers with essential information on the main natural organoselenium compounds and where they are found. Buy organoselenium compounds in biology and medicine. This book presents recent advances in and perspectives on the use of organoselenium compounds, primarily highlighting the new frontiers in the field of green chemistry, their therapeutic and. The results obtained can be divided in three main subchapters according to the approached class of compounds. Organoselenium compounds as phytochemicals from the natural kingdom. Contributions to the chemistry of organoselenium compounds. Organoselenium compounds as phytochemicals from the natural. Over the past 15 years, organoselenium reagents have been increasingly used in organic synthesis, especially for the construction of complex molecules. New frontiers in organoselenium compounds eder joao. Us20020165215a1 organoselenium compounds for cancer.
Both of these compounds have reported anticancer properties, including in breast, prostate and colon cancer cells 28. Organoselenium compounds an overview sciencedirect topics. Pdf organoselenium chemistry has emerged as an outstanding area in recent years due to its essential role in. In these populations, there is an increase in oxidative stress with augmented reactive oxygen and nitrogen species generation and decreased antioxidant defense, which. The compounds presented a significant antioxidant effect in both applied methodologies. Here, we also assessed the compounds antioxidant properties using two established methods, such as dpph and phosphomolybdenium. New frontiers in organoselenium compounds springerlink.
Download it once and read it on your kindle device, pc, phones or tablets. Organoselenium compounds modulate extracellular redox by. Waterdependent synthesis of biologically active diaryl. Between synthesis and biochemistry an excellent reference about selenium chemistry for researchers and graduate students in the field of selenium chemistry. Alexastratulat, in nutritional modulators of pain in the aging population, 2017. Organoselenium compounds in biology and medicine by vimal. The organoselenium compounds were incorporated into the diets by use of a vblender pattersonkelley co. Selected aspects of the metabolism of selenium in plants and microorganisms are also discussed. Even compounds with a longer or shorter spacer length, such as sfn 6, sfn 9, 6erucin, and phenethyl isothiocyanate, display a similar effect 37. Furthermore, both compounds produce induction of apoptosis in human gastric adenocarcinoma cells. Claudio santi, francesca marini, luana bagnoli, luca sancinetoa, martina palomba. The rate of deiodination was found to be significantly higher than that of the debromination for both.
Selenium compound an overview sciencedirect topics. Compound 77 has been the most extensively investigated. In this thesis, metabolites from natural organosulfur and organoselenium compounds, i. This book discusses organoselenium chemistry and biology in the context of its therapeutic potential, taking the reader through synthetic techniques, bioactivity and. It inhibits cell proliferation and induces apoptosis in several tumor cells. Organoselenium chemistry in stereoselective reactions wirth. Derived organoselenium compounds with glutathione peroxidase. The biochemistry and pharmacology of seleniumbased compounds are.
Glossary 2173 with the findings that organoselenium compounds are much less toxic compared with the inorganic xiv. New frontiers in organoselenium compounds request pdf. The diorganoselenium and selenides compounds electrochemistry. Similarly, other natural organoselenium compounds found in yeasts methylselenocysteine and selenomethionine also act as hdac inhibitors with potential anticancer properties 38. Article views are the countercompliant sum of full text article downloads since november 2008 both pdf and html across all institutions and individuals. Provided herein are organoselenium compounds and pharmaceutical compositions thereof. Divided into three sections, the first section describes synthetic advances in bioactive selenium compounds, revealing how. Organoselenium compounds for cancer chemoprevention download pdf info publication number us20020165215a1. Divided into three sections, the first section describes synthetic advances in bioactive selenium compounds, revealing.
Wirth, in comprehensive organometallic chemistry iii, 2007. Reich contribution from the department of chemistry, university of wisconsin. Synthesis and antioxidant properties of organosulfur and organoselenium compounds derived from 5substituted1,3,4oxadiazole. The vast majority of organoselenium compounds can be handled using the. Pdf biological importance of organoselenium compounds. Organoselenium compounds in biology and medicine rsc publishing. Selenium is naturally present in soils but it is also produced by pollution from human activities into the environment. Organoselenium compounds modulate extracellular redox by induction of extracellular cysteine and cell surface thioredoxin reductase. Also provided herein are methods of treatment, prevention, or amelioration of a variety of medical disorders using the compounds and pharmaceutical compositions provided herein. This document was downloaded for personal use only. Use features like bookmarks, note taking and highlighting while reading organoselenium compounds in biology and medicine. The control and experimental diets containing selenium compounds were prepared weekly in our laboratory and stored in a cold room. Methylselenocysteine msc and selenomethionine sm are two major organoselenium compounds present in seleniumenriched plants and yeast 1. Pdf synthetic organoselenium compounds in medicinal domain.
Organoselenium compounds in regulation of apoptosis. This book discusses organoselenium chemistry and biology in the context of its therapeutic potential, taking the reader through synthetic techniques, bioactivity and therapeutic applications. The mixed acetal 140 is then used under radical reaction conditions for the efficient formation of new carboncarbon bonds scheme 36. For example, in mouse mammary epithelial tumor cells in vitro, msc attenuated phosphatidylinositol 3. Clinical studies involving organoselenium compounds have so far focused on cancer and critically ill patients. Organoselenium chemistry is a unique resource in this branch of. Study of polymorphism of organosulfur and organoselenium. Organoselenium compounds are chemical compounds containing carbontoselenium chemical bonds. Acknowledgments 2173 organoselenium compounds in biochemistry started xiii. Conversion of ketones to enones by selenoxide syn elimination hans j. Research over last 20 years has shown that dietary selenium can prevent or reduce the incidence of naturally occurring and both chemically and virally induced cancer.
Both nucleophilic and electrophilic reagents are readily available for the introduction of selenium. Chemoprevention of carcinogenesis by organoselenium compounds. Download fulltext pdf study of polymorphism of organosulfur and organoselenium compounds article pdf available in journal of thermal analysis and calorimetry 1053. Part of the topics in current chemistry book series topcurrchem, volume 208. A number of eminent scientists from different research groups were involved in the preparation of the chapters of the book, making organoselenium chemistry.
Pages in category organoselenium compounds the following 20 pages are in this category, out of 20 total. Functional group manipulation usin organoselenium reagents. Organoselenium compounds as the oxidants and oxidation catalysts. Seleniumbased methods in synthetic chemistry have developed rapidly over the past years and are now offering highly useful tools for organic synthesis. Selenium compounds such as 77, ebselen 128 or selenodiglutathione 103, are chemopreventive in animal models, inhibit cell growth and induce apoptosis in vitro. Media in category organoselenium compounds the following 22 files are in this category, out of 22 total. Chemoprevention of colon cancer by organoselenium compounds. The ability of the organoselenium compounds to prevent oxidative damage induced by dmba in rat livers. Organoselenium compounds in biology and medicine pdf. An investigation of the influence of the compound on oxidative stress and antioxidant enzyme system. Filling the gap for a comprehensive handbook and ready reference, this book covers all modern developments within the field, including biochemical aspects.
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